It was initially extracted from the fungus Cordyceps militaris, but can now be produced synthetically. A 5'-deoxyribonucleoside compound having adenosine as the nucleobase. , Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two. , Cordycepin has been found to produce rapid, robust imipramine-like antidepressant effects in animal models of depression, and these effects, similarly to those of imipramine, are dependent on enhancement of AMPA receptor signaling. , InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1, O[C@@H]1C[C@@H](CO)O[C@H]1N2C(N=CN=C3N)=C3N=C2, n2c1c(ncnc1n(c2)[C@@H]3O[C@@H](C[C@H]3O)CO)N, Except where otherwise noted, data are given for materials in their, "The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin", "Inhibition of polyadenylation reduces inflammatory gene induction", "3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway", https://en.wikipedia.org/w/index.php?title=Cordycepin&oldid=983059846, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles with changed ChemSpider identifier, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 12 October 2020, at 00:48. Desoxyadenosin bildet mit Desoxythymidin ein Basenpaar. Merck is developing a subdermal drug-eluting implant to administer islatravir.. EC Number 211-503-1. Desoxyadenosin bildet mit Desoxythymidin ein Basenpaar. eCl@ss 32160414 . CopyCopied, InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 VAT:17.0%. Articles of 2'-Deoxyadenosine are included as well. PubChem Substance ID 24894020. CopyCopied, CSID:13135, http://www.chemspider.com/Chemical-Structure.13135.html (accessed 20:54, Oct 31, 2020) 2 S-adenosyl-L-methionine + a sulfurated [sulfur carrier] + dethiobiotin + 2 a reduced [2Fe-2S] ferredoxin -> an unsulfurated [sulfur carrier] + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized [2Fe-2S] ferredoxin, 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis, biotin biosynthesis from 8-amino-7-oxononanoate I, lipoate biosynthesis and incorporation II, 2 S-adenosyl-L-methionine + a [lipoyl-carrier protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] + 2 a reduced [2Fe-2S] ferredoxin -> a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an unsulfurated [sulfur carrier] + 2 an oxidized [2Fe-2S] ferredoxin, S-adenosyl-L-methionine + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole -> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + carbon monoxide + 3 H+, S-adenosyl-L-methionine + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole -> carbon monoxide + formate + L-methionine + 5'-deoxyadenosine + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + carbon monoxide + 3 H+ + 3 H+, S-adenosyl-L-methionine + 9-mercaptodethiobiotin -> biotin + 5'-deoxyadenosine + L-methionine + H+, S-adenosyl-L-methionine + a sulfurated [sulfur carrier] + dethiobiotin + 2 a reduced [2Fe-2S] ferredoxin + H+ -> an unsulfurated [sulfur carrier] + 9-mercaptodethiobiotin + 5'-deoxyadenosine + L-methionine + 2 an oxidized [2Fe-2S] ferredoxin, S-adenosyl-L-methionine + GTP + a reduced electron acceptor -> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + L-methionine + 5'-deoxyadenosine + an oxidized electron acceptor + H+. Es besteht aus der Nukleinbase Adenin und dem Zucker Desoxyribose. Empirical Formula (Hill Notation) C 10 H 14 N 5 O 6 P . NACRES NA.51 Das Analogon mit Ribose ist das Adenosin. CopyCopied, OLXZPDWKRNYJJZ-RRKCRQDMSA-N 2934999090. other heterocyclic compounds. Buying Leads | , Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro, and at least one clinical trial of cordycepin as a leukemia treatment is in progress. It was initially extracted from the fungus Cordyceps militaris, but can now be produced synthetically. 5'-deoxyadenosine is a 5'-deoxyribonucleoside compound having adenosine as the nucleobase. Desoxyadenosin ist einer der vier Nukleosidbausteine, aus denen DNA aufgebaut ist, und trägt das Kürzel dA. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. 2'-deoxyadenosine + ATP -> dAMP + ADP + H+. MSDS/SDS Database Search | Deoxyadenosine monophosphate (dAMP), also known as deoxyadenylic acid or deoxyadenylate in its conjugate acid and conjugate base forms, respectively, is a derivative of the common nucleic acid AMP, or adenosine monophosphate, in which the -OH group on the 2' carbon on the nucleotide's pentose has been reduced to just a hydrogen atom (hence the "deoxy-" part of the name).
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